Stationed in every tendril of a busy downtown trauma centre and thrust into frontline medical action, Nurses sees five recent graduates beginning their careers in a high-stakes hospital with pressure cooker training. Forming an inextricable bond, the nurses struggle to find a work-life balance that matches and counters the intensity of their new job. Their interaction with patients, relatives, and staff quickly leads them to the discovery that nursing isn't just about biology, chemistry, and anatomy, it's also about psychology, compassion, and romantic complications.